High gene delivery efficiency of alkylated low-molecular-weight polyethylenimine through gemini surfactant-like effect

To our knowledge, the mechanism underlying the high transfection efficiency of alkylated low-molecular-weight polyethylenimine (PEI) is not yet well understood. In this work, we grafted branched PEI (molecular weight of 1,800 Da; bPEI1800) with lauryl chains (C(12)), and found that bPEI1800-C(12) wa...

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Bibliographic Details
Main Authors: Liu, Shan, Huang, Wei, Jin, Ming-Ji, Wang, Qi-Ming, Zhang, Gan-Lin, Wang, Xiao-Min, Shao, Shuai, Gao, Zhong-Gao
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2014
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122513/
https://ncbi.nlm.nih.gov/pubmed/25114526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S64554
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