Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors. In vivo, BZ sites are potential targets for endogenous ligands regulating the corresponding central nervous system states. To...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Günther, U, Benson, J, Benke, D, Fritschy, J M, Reyes, G, Knoflach, F, Crestani, F, Aguzzi, A, Arigoni, M, Lang, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7749
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