Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Vigilance, anxiety, epileptic activity, and muscle tone can be modulated by drugs acting at the benzodiazepine (BZ) site of gamma-aminobutyric acid type A (GABAA) receptors. In vivo, BZ sites are potential targets for endogenous ligands regulating the corresponding central nervous system states. To...

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Autors principals: Günther, U, Benson, J, Benke, D, Fritschy, J M, Reyes, G, Knoflach, F, Crestani, F, Aguzzi, A, Arigoni, M, Lang, Y
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC41223/
https://ncbi.nlm.nih.gov/pubmed/7644489
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