Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum

We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol resulting from maternal infusion of cortisol (1 mg/kg/day) caused fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies we extended the cortisol infusion to term, finding a dramatic in...

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Bibliographic Details
Main Authors: Richards, Elaine M., Wood, Charles E., Rabaglino, Maria Belen, Antolic, Andrew, Keller-Wood, Maureen
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
General Interest
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121623/
https://ncbi.nlm.nih.gov/pubmed/24867915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00009.2014
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