Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea

RATIONALE: Intestinal anaphylaxis (manifested by acute diarrhea) is dependent on IgE and mast cells. OBJECTIVE: We aimed to define the respective roles of IL-4 and IL-13 and their receptors in disease pathogenesis. METHODS: Wild-type mice and mice deficient in IL-4, IL-13, and IL-13Rα1 (part of the...

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Bibliographic Details
Main Authors: Brandt, Eric B., Munitz, Ariel, Orekov, Tatyana, Mingler, Melissa K., McBride, Melissa, Finkelman, Fred D., Rothenberg, Marc E.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121593/
https://ncbi.nlm.nih.gov/pubmed/18996576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2008.10.001
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