Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis

IL-13 and IL-4 are central T helper 2 (Th2) cytokines in the immune system and potent activators of inflammatory responses and fibrosis during Th2 inflammation. Recent studies using Il13ra1(−/−) mice have demonstrated a critical role for IL-13 receptor (IL-13R) α1 in allergen-induced airway response...

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Main Authors: Munitz, A., Brandt, E. B., Mingler, M., Finkelman, F. D., Rothenberg, M. E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386078/
https://ncbi.nlm.nih.gov/pubmed/18480254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802465105
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