Intracellular delivery of acetyl-histone peptides inhibits native bromodomain-chromatin interactions and impairs mitotic progression

Bromodomains present in Brd4 and other chromatin proteins interact with acetylated histones to regulate transcription and cell growth. To study Brd4-chromatin interactions in vivo, histone H4 tail peptides were fused to a synthetic protein transduction domain (PTD) derived from the human immunodefic...

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Main Authors: Nishiyama, Akira, Mochizuki, Kazuki, Mueller, Florian, Karpova, Tatiana, McNally, James G., Ozato, Keiko
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120274/
https://ncbi.nlm.nih.gov/pubmed/18396160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.03.044
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