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Studying the organization of DNA repair by single-cell and single-molecule imaging

DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms of many repair proteins have been examined separately in vitro, far less is known about the coordinated function of the whole repair machinery in vivo. Furthermore, single-cell studies indicate that...

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Autors principals: Uphoff, Stephan, Kapanidis, Achillefs N.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119245/
https://ncbi.nlm.nih.gov/pubmed/24629485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.02.015
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