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The RING Finger Protein MSL2 in the MOF Complex is an E3 Ubiquitin Ligase for H2B K34 and is Involved in Crosstalk with H3 K4 and K79 Methylation
We demonstrate that RING finger protein MSL2 in the MOF-MSL complex is a histone ubiquitin E3 ligase. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34 (H2B K34ub), a site within a conserved basic patch on H2B tail. H2B K34ub by MSL...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119175/ https://ncbi.nlm.nih.gov/pubmed/21726816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.05.015 |
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