Successful treatment of a patient with Li–Fraumeni syndrome and metastatic lung adenocarcinoma harboring synchronous EGFR L858R and ERBB2 extracellular domain S310F mutations with the pan-HER inhibitor afatinib

We report the case of a young, never-smoker woman with Li–Fraumeni syndrome and advanced lung adenocarcinoma refractory to multiple lines of conventional chemotherapy and negative for actionable alterations by routine testing. Comprehensive genomic profiling by clinical-grade next generation sequenc...

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Detalhes bibliográficos
Main Authors: Jia, Yuxia, Ali, Siraj M, Saad, Shumaila, Chan, Courtney A, Miller, Vincent A, Halmos, Balazs
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Bedside to Bench Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119081/
https://ncbi.nlm.nih.gov/pubmed/24835218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29173
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