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A Salmonella Typhimurium mutant strain capable of RNAi delivery: Higher tumor-targeting and lower toxicity
Bacteria are highly versatile and useful tools that could deliver short interfering RNA. In this study, a phoP/phoQ double-deleted Salmonella Typhimurium named VNP(PhoP/Q(−)) based on the genetic background of VNP20009. The biological safety and function of VNP(PhoP/Q(−)) were also analyzed. Our stu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119074/ https://ncbi.nlm.nih.gov/pubmed/24842165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29185 |
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