Interpreting treatment effects from clinical trials in the context of real-world risk information: the example of end-stage renal disease prevention in older adults

IMPORTANCE: Older adults are often excluded from clinical trials. The benefit of preventive interventions tested in younger trial populations may be reduced when applied to older adults in the clinical setting if they are less likely to survive long enough to experience those outcomes targeted by th...

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Главные авторы: O’Hare, Ann M., Hotchkiss, John R., Tamura, Manjula Kurella, Larson, Eric B., Hemmelgarn, Brenda R., Batten, Adam, Do, Thy P., Covinsky, Kenneth E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119007/
https://ncbi.nlm.nih.gov/pubmed/24424348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamainternmed.2013.13328
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