EZH2 Is Associated with Malignant Behavior in Pancreatic IPMN via p27(Kip1) Downregulation

BACKGROUND: The epigenetic mechanism of tumorigenesis in pancreatic intraductal papillary mucinous neoplasm (IPMN) remains largely unknown. The aim of this study is to examine the role of enhancer of zeste homologue 2 (EZH2) alteration in pancreatic IPMN progression. METHODS: Fifty-four surgically r...

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Detalhes bibliográficos
Main Authors: Kuroki, Hideyuki, Hayashi, Hiromitsu, Okabe, Hirohisa, Hashimoto, Daisuke, Takamori, Hiroshi, Nakahara, Osamu, Nakagawa, Shigeki, Fukushima, Yukiko, Chikamoto, Akira, Beppu, Toru, Hirota, Masahiko, Iyama, Ken-ichi, Baba, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118850/
https://ncbi.nlm.nih.gov/pubmed/25084021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100904
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