p53 deficiency does not affect the accumulation of point mutations in a transgene target.

DNA repair is required by organisms to prevent the accumulation of mutations and to maintain the integrity of genetic information. Mammalian cells that have been treated with agents that damage DNA have an increase in p53 levels, a p53-dependent arrest at G1 in the cell cycle, and a p53-dependent ap...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Sands, A T, Suraokar, M B, Sanchez, A, Marth, J E, Donehower, L A, Bradley, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41188/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8517
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