Validation of a Janus role of methotrexate-based PEGylated chitosan nanoparticles in vitro

Recently, methotrexate (MTX) has been used to target to folate (FA) receptor-overexpressing cancer cells for targeted drug delivery. However, the systematic evaluation of MTX as a Janus-like agent has not been reported before. Here, we explored the validity of using MTX playing an early-phase cancer...

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Bibliographic Details
Main Authors: Luo, Fanghong, Li, Yang, Jia, Mengmeng, Cui, Fei, Wu, Hongjie, Yu, Fei, Lin, Jinyan, Yang, Xiangrui, Hou, Zhenqing, Zhang, Qiqing
Format: Artigo
Language:Inglês
Published: Springer 2014
Subjects:
Nano Express
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118220/
https://ncbi.nlm.nih.gov/pubmed/25114653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1556-276X-9-363
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