F-Box Only Protein 31 (FBXO31) Negatively Regulates p38 Mitogen-activated Protein Kinase (MAPK) Signaling by Mediating Lysine 48-linked Ubiquitination and Degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)

The p38 MAPK signal transduction pathway plays an important role in inflammatory and stress responses. MAPKK6 (MKK6), a dual specificity protein kinase, is a p38 activator. Activation of the MKK6-p38 pathway is kept in check by multiple layers of regulations, including autoinhibition, dimerization,...

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Detalhes bibliográficos
Main Authors: Liu, Jia, Han, Liang, Li, Bin, Yang, Jie, Huen, Michael S. Y., Pan, Xin, Tsao, Sai Wah, Cheung, Annie L. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118112/
https://ncbi.nlm.nih.gov/pubmed/24936062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560342
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