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Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine

N7-Methyl-2′-deoxyguanosine (m7dG) is the predominant lesion formed by methylating agents. A systematic investigation on the effect of m7dG on DNA replication has been difficult due to the chemical instability of m7dG. To gain insights into the m7dG effect, we employed a 2′-fluorine-mediated transit...

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Bibliografiske detaljer
Main Authors: Koag, Myong-Chul, Kou, Yi, Ouzon-Shubeita, Hala, Lee, Seongmin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117778/
https://ncbi.nlm.nih.gov/pubmed/24966350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku554
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