ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

Ataxia-telangiectasia mutated (ATM), a member of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double strand DNA break-repair pathway after genotoxic stress. Here, we found ATM serves as an essential regulator of TNF-induced NF-kB pathway. We observed that TNF ex...

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Detalhes bibliográficos
Main Authors: Fang, Ling, Choudhary, Sanjeev, Zhao, Yingxin, Edeh, Chukwudi B, Yang, Chunying, Boldogh, Istvan, Brasier, Allan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117761/
https://ncbi.nlm.nih.gov/pubmed/24957606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku529
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