Zaprinast and Rolipram Enhances Spatial and Emotional Memory in the Elevated Plus Maze and Passive Avoidance Tests and Diminishes Exploratory Activity in Naive Mice

BACKGROUND: Phosphodiesterase (PDE) inhibitors in the central nervous system have been shown to stimulate neuronal functions and increase neurogenesis in Alzheimer disease (AD) patients. MATERIAL/METHODS: The aim of this study was to investigate the effects of zaprinast, a PDE(5) inhibitor, and roli...

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Autores principales: Akar, Furuzan, Mutlu, Oguz, Celikyurt, Ipek Komsuoglu, Ulak, Guner, Erden, Faruk, Bektas, Emine, Tanyeri, Pelin
Formato: Artigo
Lenguaje:Inglês
Publicado: International Scientific Literature, Inc. 2014
Materias:
Pharmaceutical Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117679/
https://ncbi.nlm.nih.gov/pubmed/25057848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.891149
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