Single-Cell Genome-Wide Bisulfite Sequencing for Assessing Epigenetic Heterogeneity

We report a single-cell bisulfite sequencing method (scBS-Seq) capable of accurately measuring DNA methylation at up to 48.4% of CpGs. We observed that ESCs grown in serum or 2i both display epigenetic heterogeneity, with “2i-like” cells present in serum cultures. In silico integration of 12 individ...

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Bibliografiske detaljer
Main Authors: Smallwood, Sébastien A, Lee, Heather J, Angermueller, Christof, Krueger, Felix, Saadeh, Heba, Peat, Julian, Andrews, Simon R, Stegle, Oliver, Reik, Wolf, Kelsey, Gavin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117646/
https://ncbi.nlm.nih.gov/pubmed/25042786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3035
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