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Triene prostaglandins: Prostaglandin D(3) and icosapentaenoic acid as potential antithrombotic substances

Addition of the 3-series fatty acid precursor (icosapentaenoic acid, IPA), its endoperoxide [prostaglandin (PG)H(3)], or thromboxane A(3) to human platelet-rich plasma (PRP) does not result in aggregation of the platelets. In fact, preincubation of human PRP with exogenous PGH(3) actually inhibited...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Whitaker, Mark O., Wyche, Angela, Fitzpatrick, Frank, Sprecher, Howard, Needleman, Philip
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1979
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/230492/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.11.5919
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