Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling

Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) secrete soluble factor TGF-β1 to support BBB integrity. Firstly, we prepared con...

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Autores principales: Seo, Ji Hae, Maki, Takakuni, Maeda, Mitsuyo, Miyamoto, Nobukazu, Liang, Anna C., Hayakawa, Kazuhide, Pham, Loc-Duyen D., Suwa, Fumihiko, Taguchi, Akihiko, Matsuyama, Tomohiro, Ihara, Masafumi, Kim, Kyu-Won, Lo, Eng H., Arai, Ken
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117639/
https://ncbi.nlm.nih.gov/pubmed/25078775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103174
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