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Regulation of Feto-Maternal Barrier by Matriptase- and PAR-2-Mediated Signaling Is Required for Placental Morphogenesis and Mouse Embryonic Survival

The development of eutherian mammalian embryos is critically dependent on the selective bi-directional transport of molecules across the placenta. Here, we uncover two independent and partially redundant protease signaling pathways that include the membrane-anchored serine proteases, matriptase and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Szabo, Roman, Peters, Diane E., Kosa, Peter, Camerer, Eric, Bugge, Thomas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117450/
https://ncbi.nlm.nih.gov/pubmed/25078604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004470
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