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Single-molecule sequencing of an individual human genome

Recent advances in high-throughput DNA sequencing technologies have enabled order-of-magnitude improvements in both cost and throughput. Here we report the use of single-molecule methods to sequence an individual human genome. We aligned billions of 24- to 70-bp reads (32 bp average) to ~90% of the...

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Main Authors: Pushkarev, Dmitry, Neff, Norma F, Quake, Stephen R
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117198/
https://ncbi.nlm.nih.gov/pubmed/19668243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1561
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