A Novel TLR-9 Agonist C792 Inhibits Plasmacytoid Dendritic Cell-induced Myeloma Cell Growth and Enhance Cytotoxicity of Bortezomib

Our prior study in multiple myeloma (MM) patients showed increased numbers of plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) which both contribute to immune dysfunction as well as promote tumor cell growth, survival, and drug resistance. Here we show that a novel Toll-Like Receptor (TLR...

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Autori principali: Ray, Arghya, Tian, Ze, Das, Deepika Sharma, Coffman, Robert L., Richardson, Paul, Chauhan, Dharminder, Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116471/
https://ncbi.nlm.nih.gov/pubmed/24476765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.46
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