Siglec-G/10 in self–nonself discrimination of innate and adaptive immunity

Siglec-G/10 is broadly expressed on B cells, dendritic cells and macrophage subsets. It binds strongly to CD24, a small glycosyl-phosphatidylinositol-anchored sialoprotein, in a sialylation-dependent manner. Targeted mutation of Siglecg dramatically elevates the level of natural IgM antibodies and i...

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Autores principales: Chen, Guo-Yun, Brown, Nicholas K, Zheng, Pan, Liu, Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Special Issue - Reviews on Emerging Roles of Siglecs in Health and Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116048/
https://ncbi.nlm.nih.gov/pubmed/24996822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwu068
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