Targeted Gene Sequencing to Identify Polymorphisms in the Protein C and EPCR Genes in Patients with Unprovoked Venous Thromboembolism

OBJECTIVE: The interaction of protein C (PC) with the endothelial protein C receptor (EPCR) enhances activated PC (APC) generation. We performed targeted gene sequencing of the PC gene (PROC) and EPCR genes (PROCR) in patients with unprovoked venous thromboembolism (VTE) to determine if mutations th...

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Autors principals: Wu, Cynthia, Dwivedi, Dhruva, Pepler, Laura, Lysov, Zakhar, Waye, John, Julian, Jim, Desch, Karl, Ginsburg, David, Weitz, Jeffrey I., Kearon, Clive, Liaw, Patricia
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115806/
https://ncbi.nlm.nih.gov/pubmed/24051141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302137
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