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Activation of Extracellular Signal-Regulated Kinase 5 Reduces Cardiac Apoptosis and Dysfunction via Inhibition of a Phosphodiesterase 3A/Inducible cAMP Early Repressor Feedback Loop

Substantial evidence suggests that the progressive loss of cardiomyocytes caused by apoptosis significantly contributes to the development of heart failure. β-Adrenergic receptor activation and subsequent persistent phosphodiesterase 3A (PDE3A) downregulation and concomitant inducible cAMP early rep...

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Detalhes bibliográficos
Main Authors: Yan, Chen, Ding, Bo, Shishido, Tetsuro, Woo, Chang-Hoon, Itoh, Seigo, Jeon, Kye-Im, Liu, Weimin, Xu, Haodong, McClain, Carolyn, Molina, Carlos A., Blaxall, Burns C., Abe, Jun-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115673/
https://ncbi.nlm.nih.gov/pubmed/17272811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000259045.49371.9c
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