Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts.

Human beta-glucuronidase (beta-D-glucuronide glucuronosohydrolase, EC 3.2.1.31), like many other glycoprotein lysosomal hydrolases, is subject to receptor-mediated endocytosis by fibroblasts. Prior work demonstrated charge heterogeneity in beta-glucuronidase and showed that high-uptake forms are mor...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Natowicz, M R, Chi, M M, Lowry, O H, Sly, W S
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1979
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC411566/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/291966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.9.4322
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