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Detouring of cisplatin to access mitochondrial genome for overcoming resistance

Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a rationally designed therapy for metastatic...

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Bibliografiske detaljer
Main Authors: Marrache, Sean, Pathak, Rakesh K., Dhar, Shanta
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115573/
https://ncbi.nlm.nih.gov/pubmed/25002500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405244111
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