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Detouring of cisplatin to access mitochondrial genome for overcoming resistance
Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a rationally designed therapy for metastatic...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115573/ https://ncbi.nlm.nih.gov/pubmed/25002500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405244111 |
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