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Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells

Induced pluripotent stem (iPS) cells hold great promise for regenerative medicine. To overcome potential problems associated with transgene insertions, efforts have been directed over the past several years to generate transgene-free iPS cells by using non-viral-vector approaches. To date, however,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wu, Sen, Wu, Yuanyuan, Zhang, Xi, Capecchi, Mario R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115572/
https://ncbi.nlm.nih.gov/pubmed/25002522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409933111
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