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Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells

Induced pluripotent stem (iPS) cells hold great promise for regenerative medicine. To overcome potential problems associated with transgene insertions, efforts have been directed over the past several years to generate transgene-free iPS cells by using non-viral-vector approaches. To date, however,...

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Bibliografiske detaljer
Main Authors: Wu, Sen, Wu, Yuanyuan, Zhang, Xi, Capecchi, Mario R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115572/
https://ncbi.nlm.nih.gov/pubmed/25002522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409933111
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