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Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells

Induced pluripotent stem (iPS) cells hold great promise for regenerative medicine. To overcome potential problems associated with transgene insertions, efforts have been directed over the past several years to generate transgene-free iPS cells by using non-viral-vector approaches. To date, however,...

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Bibliographic Details
Main Authors: Wu, Sen, Wu, Yuanyuan, Zhang, Xi, Capecchi, Mario R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115572/
https://ncbi.nlm.nih.gov/pubmed/25002522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409933111
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