Direct Evidence for Calcineurin Binding to the Exon-7 Loop of the Sodium-Bicarbonate Cotransporter NBCn1

The NaHCO(3 )cotransporter NBCn1 plays a role in neutralizing intracellular acid loads at the basolateral membrane in cells of the medullary thick ascending limb (mTAL). Calcineurin inhibitors (Cn-Is) are known to both downregulate NBCn1 expression in the distal nephron and cause renal tubular acido...

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Hlavní autoři: Gill, Harindarpal S., Roush, Eric D., Dutcher, Lauren, Patel, Samir
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2014
Témata:
Short Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115197/
https://ncbi.nlm.nih.gov/pubmed/25076853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.9539
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