Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

Acid-sensing ion channel 1A (ASIC1A) is abundant in the nucleus accumbens (NAc), a region known for its role in addiction. Because ASIC1A has been previously suggested to promote associative learning, we hypothesized that disrupting ASIC1A in the NAc would reduce drug-associated learning and memory....

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Autori principali: Kreple, Collin J., Lu, Yuan, Taugher, Rebecca J., Schwager-Gutman, Andrea L., Du, Jianyang, Stump, Madeliene, Wang, Yimo, Ghobbeh, Ali, Fan, Rong, Cosme, Caitlin V., Sowers, Levi P., Welsh, Michael J., Radley, Jason J., LaLumiere, Ryan T., Wemmie, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115047/
https://ncbi.nlm.nih.gov/pubmed/24952644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3750
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