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Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
BACKGROUND: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than commonly used 2D and 3D cell line models. Such structures harbour tumorigenic ce...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4114130/ https://ncbi.nlm.nih.gov/pubmed/25075203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-12-39 |
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