Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo

Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or...

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Autores principales: Chu, Derek K., Jimenez-Saiz, Rodrigo, Verschoor, Christopher P., Walker, Tina D., Goncharova, Susanna, Llop-Guevara, Alba, Shen, Pamela, Gordon, Melissa E., Barra, Nicole G., Bassett, Jennifer D., Kong, Joshua, Fattouh, Ramzi, McCoy, Kathy D., Bowdish, Dawn M., Erjefält, Jonas S., Pabst, Oliver, Humbles, Alison A., Kolbeck, Roland, Waserman, Susan, Jordana, Manel
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113937/
https://ncbi.nlm.nih.gov/pubmed/25071163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131800
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