Differential analysis of N-glycoproteome between hepatocellular carcinoma and normal human liver tissues by combination of multiple protease digestion and solid phase based labeling

BACKGROUND: Dysregulation of glycoproteins is closely related with many diseases. Quantitative proteomics methods are powerful tools for the detection of glycoprotein alterations. However, in almost all quantitative glycoproteomics studies, trypsin is used as the only protease to digest proteins. Th...

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Main Authors: Sun, Zhen, Sun, Deguang, Wang, Fangjun, Cheng, Kai, Zhang, Zhang, Xu, Bo, Ye, Mingliang, Wang, Liming, Zou, Hanfa
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112855/
https://ncbi.nlm.nih.gov/pubmed/25097464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1559-0275-11-26
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