A mechanistic role for the chromatin modulator, NAP1L1, in pancreatic neuroendocrine neoplasm proliferation and metastases

BACKGROUND: The chromatin remodeler NAP1L1, which is upregulated in small intestinal neuroendocrine neoplasms (NENs), has been implicated in cell cycle progression. As p57(Kip2) (CDKN1C), a negative regulator of proliferation and a tumor suppressor, is controlled by members of the NAP1 family, we te...

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Detalhes bibliográficos
Main Authors: Schimmack, Simon, Taylor, Andrew, Lawrence, Ben, Alaimo, Daniele, Schmitz-Winnenthal, Hubertus, Büchler, Markus W, Modlin, Irvin M, Kidd, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112619/
https://ncbi.nlm.nih.gov/pubmed/25071868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-7-15
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