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Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects

Brain derived neurotrophic factor (BDNF) signaling through its receptor TrkB plays a crucial role in neurodevelopment and plasticity. Stress and glucocorticoids have been shown to alter TrkB signaling in neurons, and defects in TrkB expression have been reported in the prefrontal cortex of suicide s...

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Main Authors: Pandya, Chirayu, Kutiyanawalla, Ammar, Turecki, Gustavo, Pillai, Anilkumar
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112477/
https://ncbi.nlm.nih.gov/pubmed/24845182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2014.03.020
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