Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≥15 mg may be overcome with subcutaneous administration

OBJECTIVE: To compare the relative bioavailability, safety and tolerability of oral methotrexate (MTX) and subcutaneous (SC) MTX administered via an auto-injector (MTXAI) in patients with rheumatoid arthritis (RA). METHODS: In this randomised, multicenter, open-label, three-way crossover study, pati...

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Detalhes bibliográficos
Main Authors: Schiff, Michael H, Jaffe, Jonathan S, Freundlich, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Clinical and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112421/
https://ncbi.nlm.nih.gov/pubmed/24728329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205228
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