Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis

Pharmacological inhibition of Drosophila Polo kinase with BI2536 has allowed us to re-examine the requirements for Polo during Drosophila male gametogenesis. BI2536-treated spermatocytes persisted in a pro-metaphase state without dividing and had condensed chromosomes that did not separate. Centroso...

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Bibliographic Details
Main Authors: Riparbelli, Maria G, Gottardo, Marco, Glover, David M, Callaini, Giuliano
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111698/
https://ncbi.nlm.nih.gov/pubmed/24802643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29083
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