The Use of Directed Evolution to Create a Stable and Immunogenic Recombinant BCG Expressing a Modified HIV-1 Gag Antigen

Numerous features make Mycobacterium bovis BCG an attractive vaccine vector for HIV. It has a good safety profile, it elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable. Despite these advantages it is often difficult to express viral antigens in BCG, wh...

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Detalhes bibliográficos
Main Authors: Chapman, Rosamund, Bourn, William R., Shephard, Enid, Stutz, Helen, Douglass, Nicola, Mgwebi, Thandi, Meyers, Ann, Chin'ombe, Nyasha, Williamson, Anna-Lise
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111510/
https://ncbi.nlm.nih.gov/pubmed/25061753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103314
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