Down-Regulation of Complement Receptors on the Surface of Host Monocyte Even as In Vitro Complement Pathway Blocking Interferes in Dengue Infection

In dengue virus (DENV) infection, complement system (CS) activation appears to have protective and pathogenic effects. In severe dengue fever (DF), the levels of DENV non-structural-1 protein and of the products of complement activation, including C3a, C5a and SC5b-9, are higher before vascular leak...

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Main Authors: Marinho, Cintia Ferreira, Azeredo, Elzinandes Leal, Torrentes-Carvalho, Amanda, Marins-Dos-Santos, Alessandro, Kubelka, Claire Fernandes, de Souza, Luiz José, Cunha, Rivaldo Venâncio, de-Oliveira-Pinto, Luzia Maria
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111305/
https://ncbi.nlm.nih.gov/pubmed/25061945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102014
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