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Liver tissue engineering in the evaluation of drug safety

Assessment of drug–liver interactions is an integral part of predicting the safety profile of new drugs. Existing model systems range from in vitro cell culture models to FDA-mandated animal tests. Data from these models often fail, however, to predict human liver toxicity, resulting in costly failu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dash, Ajit, Inman, Walker, Hoffmaster, Keith, Sevidal, Samantha, Kelly, Joan, Obach, R Scott, Griffith, Linda G, Tannenbaum, Steven R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110978/
https://ncbi.nlm.nih.gov/pubmed/19637986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425250903160664
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