Increased uptake of [(123)I]-meta-iodobenzylguanidine and [(18)F]-dopamine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors romidepsin and trichostatin A

PURPOSE: [(131)I]-meta-iodobenzylguanidine ([(131)I]-MIBG) is the most commonly employed treatment for metastatic pheochromocytoma and paraganglioma; however, its success is limited. Its efficacy depends on the [(131)I]-MIBG concentration reached within the tumor through its uptake via the norepinep...

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Autors principals: Martiniova, Lucia, Perera, Shiromi M., Brouwers, Frederieke M., Alesci, Salvatore, Abu-Asab, Mones, Marvelle, Amanda F., Kiesewetter, Dale O., Thomasson, David, Morris, John C., Kvetnansky, Richard, Tischler, Arthur S., Reynolds, James C, Fojo, A. Tito, Pacak, Karel
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110720/
https://ncbi.nlm.nih.gov/pubmed/21098082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/ERC-10-0090
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