Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

Tumor necrosis factor (TNF) is selectively cytotoxic to some types of tumor cells in vitro and exerts antitumor activity in vivo. Reactive oxygen intermediates (ROIs) have been implicated in the direct cytotoxic activity of TNF. By using confocal microscopy, flow cytometry, and the ROI-specific prob...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Goossens, V, Grooten, J, De Vos, K, Fiers, W
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41106/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667254/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8115
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