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Nucleolar Stress Induces Ubiquitination-independent Proteasomal Degradation of PICT1 Protein
The nucleolar protein PICT1 regulates tumor suppressor p53 by tethering ribosomal protein L11 within the nucleolus to repress the binding of L11 to the E3 ligase MDM2. PICT1 depletion results in the release of L11 to the nucleoplasm to inhibit MDM2, leading to p53 activation. Here, we demonstrate th...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4110288/ https://ncbi.nlm.nih.gov/pubmed/24923447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571893 |
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