MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression

Polycomb group protein Ezh2 is a histone H3 Lys-27 histone methyltransferase orchestrating an extensive epigenetic regulatory program. Several nervous system-specific genes are known to be repressed by Ezh2 in stem cells and derepressed during neuronal differentiation. However, the molecular mechani...

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Autori principali: Neo, Wen Hao, Yap, Karen, Lee, Suet Hoay, Looi, Liang Sheng, Khandelia, Piyush, Neo, Sheng Xiong, Makeyev, Eugene V., Su, I-hsin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110287/
https://ncbi.nlm.nih.gov/pubmed/24878960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525493
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