The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region: IMPLICATIONS FOR FUNCTIONAL ACTIVITY

Human IgG4 antibody shows therapeutically useful properties compared with the IgG1, IgG2, and IgG3 subclasses. Thus IgG4 does not activate complement and shows conformational variability. These properties are attributable to its hinge region, which is the shortest of the four IgG subclasses. Using h...

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Detalhes bibliográficos
Main Authors: Rayner, Lucy E., Hui, Gar Kay, Gor, Jayesh, Heenan, Richard K., Dalby, Paul A., Perkins, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110284/
https://ncbi.nlm.nih.gov/pubmed/24876381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572404
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