An Interactive Network of Elastase, Secretases, and PAR-2 Protein Regulates CXCR1 Receptor Surface Expression on Neutrophils

CXCL8 (IL-8) recruits and activates neutrophils through the G protein-coupled chemokine receptor CXCR1. We showed previously that elastase cleaves CXCR1 and thereby impairs antibacterial host defense. However, the molecular intracellular machinery involved in this process remained undefined. Here we...

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Detalhes bibliográficos
Main Authors: Bakele, Martina, Lotz-Havla, Amelie S., Jakowetz, Anja, Carevic, Melanie, Marcos, Veronica, Muntau, Ania C., Gersting, Soeren W., Hartl, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110266/
https://ncbi.nlm.nih.gov/pubmed/24914212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575803
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